1 01:00:07,239 --> 01:00:08,639 Thank you for giving me the opportunity to present 2 01:00:08,639 --> 01:00:16,159 DiamPark. Our job is to measure the symptoms of Parkinson's disease in order to better 3 01:00:16,159 --> 01:00:22,320 treat it. I am Djamchid Dalili, the founder of DiamPark. 4 01:00:22,320 --> 01:00:28,360 And in the next 15 minutes, which is about the length of this presentation, one of the 5 01:00:28,360 --> 01:00:33,480 neurons in my brain will shut down. This neuron will die because I myself have 6 01:00:33,480 --> 01:00:38,840 Parkinson's disease. And besides, I'm not the only one. 7 01:00:38,840 --> 01:00:44,920 As you have heard, there are 160,000 of us in France and 6 million in the world. With the 8 01:00:44,920 --> 01:00:51,360 aging of the world population, in 2030, we will be 10 million. It was this realization 9 01:00:51,360 --> 01:00:53,920 that triggered my tenth life. 10 01:00:53,920 --> 01:01:01,119 I'm talking about my tenth life because I've lived nine lives before. 11 01:01:01,119 --> 01:01:09,440 In my ninth life I trained 6,000 web developers who didn't know how to program and 12 01:01:09,440 --> 01:01:13,800 led them to a job as a computer technician. 13 01:01:13,800 --> 01:01:22,039 And it was this experience as an IT entrepreneur that I used to create DiamPark, 14 01:01:22,039 --> 01:01:25,159 which I want to tell you about. 15 01:01:25,159 --> 01:01:34,639 I'm not going to tell you my ten lives in full, but in my lives number 4, 5 and 6. 16 01:01:34,679 --> 01:01:40,039 I had accumulated a rather interesting scientific base through my studies at the 17 01:01:40,039 --> 01:01:45,480 Ecole Polytechnique, my doctorate in nuclear physics and my years of research and 18 01:01:45,480 --> 01:01:53,239 development at Pechiney. This, too, would help in the development of DiamPark to help 19 01:01:53,239 --> 01:01:56,159 fight Parkinson's disease. 20 01:01:58,239 --> 01:02:05,639 So it's been almost five years since I was diagnosed and each year has been marked by a 21 01:02:05,639 --> 01:02:13,199 major milestone often the development of a new neuro marker for Parkinson's disease. 22 01:02:13,199 --> 01:02:20,000 As I said, our job is to measure Parkinson's disease in order to treat it better. And so, 23 01:02:20,000 --> 01:02:24,639 it goes through the intermediary of neuromarkers that I want to detail in a moment. It 24 01:02:24,639 --> 01:02:33,760 starts with my personal story, but in fact, the story of DiamPark is the commitment and 25 01:02:33,760 --> 01:02:42,519 the meeting of many caring people, including Nathalie George, who spoke just now. 26 01:02:42,559 --> 01:02:50,119 But I started with Didier Tranchier, who was my partner in my previous venture, who was 27 01:02:50,119 --> 01:02:57,679 also my mentor-investor in this company and who is a polytechnician like me and who, in 28 01:02:57,679 --> 01:03:04,719 the meantime, had created Digital Pharma Lab, which is a pharma tech accelerator. 29 01:03:04,719 --> 01:03:10,159 So, Didier introduced me to Pascal Bécache, who was his co-founder at Digital Pharma 30 01:03:10,159 --> 01:03:15,079 Lab, who knows a lot about the pharmaceutical industry and has mastered data 31 01:03:15,079 --> 01:03:20,800 in the pharmaceutical industry. Data is the essential basis of the raw material, of what 32 01:03:20,800 --> 01:03:28,239 we process. And Pascal Bécache introduced me to Yohan Attal, who is in the room and who is 33 01:03:28,239 --> 01:03:31,320 an alumnus of the Brain Institute. 34 01:03:31,320 --> 01:03:38,360 And Yohan Attal introduced me to the Brain Institute, for example, Alexis Genin, who is 35 01:03:38,360 --> 01:03:42,760 the Director of Innovation and Research Development. 36 01:03:42,800 --> 01:03:49,119 And Alexis introduced me to all the rest of the Brain Institute with whom I have the 37 01:03:49,119 --> 01:03:55,880 pleasure and honor of working and for example with Arlette, who is in the front row here. 38 01:03:57,440 --> 01:04:01,840 I'll come back a little bit to the collaboration we have together on this. Julie 39 01:04:01,840 --> 01:04:08,559 Sauzin, who has been hired full time at the Brain Institute's Living Lab to serve as an 40 01:04:08,559 --> 01:04:15,360 interface with patients, between Parkinson's patients and DiamPark's research and 41 01:04:15,360 --> 01:04:16,880 development, etc. 42 01:04:16,880 --> 01:04:23,960 Etc. And a lot of good people have looked into the cradle of the DiamPark Cie to 43 01:04:23,960 --> 01:04:27,880 talk specifically about the Brain Institute. 44 01:04:27,920 --> 01:04:36,920 With everything, with the firepower here, we have access to a network of scientists such 45 01:04:36,920 --> 01:04:41,880 as Professor Corvol, whom you heard a moment ago. 46 01:04:41,880 --> 01:04:48,440 Of both scientific and medical expertise and access to patients. 47 01:04:48,440 --> 01:04:54,760 I told you about Yohan earlier. 48 01:04:54,760 --> 01:04:59,480 He created a company called My Brain Technology, which specializes in 49 01:04:59,480 --> 01:05:05,360 electroencephalogram measurements, which we talked about a moment ago with Nathalie 50 01:05:05,360 --> 01:05:11,760 George. And thanks to the partnership with My Brain Technology, we benefit 51 01:05:11,760 --> 01:05:17,639 from several years of experience in artificial intelligence processing of brain 52 01:05:17,639 --> 01:05:23,800 data and at the same time, we have access to an IT platform that is already certified. It 53 01:05:23,800 --> 01:05:28,079 saves us years in the R&D I was telling you about. 54 01:05:28,079 --> 01:05:34,719 My obsession is to go fast because my condition is going to deteriorate and what I 55 01:05:34,719 --> 01:05:41,960 hope is that we can accelerate the release of medication enough so that myself and the 10 56 01:05:41,960 --> 01:05:45,079 million people behind me can benefit. 57 01:05:45,400 --> 01:05:50,920 So anything that speeds up is good. At the same time, in France, we benefit from a 58 01:05:50,920 --> 01:05:58,320 regulatory and financial environment that is extremely favorable to start-ups and 59 01:05:58,320 --> 01:06:01,760 everything related to digital health. 60 01:06:01,800 --> 01:06:09,639 And so, that's how we got seed funding for DeepTech from the BPI, for example, to start. 61 01:06:09,639 --> 01:06:16,480 What I'm trying to tell you is that we've started a virtuous circle of getting a lot of 62 01:06:16,480 --> 01:06:23,239 people working together at the Brain Institute, but also the whole environment around 63 01:06:23,239 --> 01:06:29,519 it so that we can get quick results. I'll come back to this diagram in a moment. I'm 64 01:06:29,519 --> 01:06:36,079 going to explain just a little bit of this diagram. One of DiamPark's goals is to provide 65 01:06:36,079 --> 01:06:40,239 free and useful services to patients. 66 01:06:40,239 --> 01:06:45,880 In this context, for example, we are participating in the creation of a 67 01:06:45,880 --> 01:06:51,480 pedagogical tool for therapeutic education in Parkinson's disease. 68 01:06:51,480 --> 01:07:00,920 This tool was designed by Professor Grabli and Arlette Welaratne, who is 69 01:07:00,920 --> 01:07:03,079 here in the room. 70 01:07:03,079 --> 01:07:08,840 And so, we're helping to create this tool because I told you in my previous life, I 71 01:07:08,840 --> 01:07:14,679 trained a few thousand web application developers and so I have the ability to tap 72 01:07:14,679 --> 01:07:20,880 into that network and go relatively fast in anything that's application development. 73 01:07:20,880 --> 01:07:24,400 Well, the team is ready. 74 01:07:24,400 --> 01:07:28,760 Now we're going to get into the subject because once the team is in place and the 75 01:07:28,760 --> 01:07:38,119 tools are there, we have to act. From the beginning, I realized that there were not 76 01:07:38,119 --> 01:07:44,519 many therapies for Parkinson's disease on the market and that research and development was 77 01:07:44,519 --> 01:07:51,679 not going fast enough in this field. However, all the pharmaceutical companies you see on 78 01:07:51,679 --> 01:07:55,360 this slide are working on clinical trials. 79 01:07:55,360 --> 01:08:01,239 You saw in Professor Corvol's slides earlier, all the molecules that are examined. There 80 01:08:01,239 --> 01:08:06,039 are over 200 interventional clinical trials each year. 81 01:08:06,039 --> 01:08:12,199 There is $8 billion in drug sales per year in Parkinson's disease. 82 01:08:12,199 --> 01:08:18,800 There is 1 billion dollars of R&D and the results are slow in coming. If the results 83 01:08:18,800 --> 01:08:24,680 are slow in coming, there must still be a problem. And Professor Corvol, rightly 84 01:08:24,680 --> 01:08:32,159 mentioned that the cycle was very, very long in the development of drugs. And that's where 85 01:08:32,159 --> 01:08:40,239 I focused my attention, saying we could make a significant contribution by enabling a very 86 01:08:40,239 --> 01:08:44,600 accurate measurement of Parkinson's symptoms. 87 01:08:44,640 --> 01:08:50,520 You saw earlier, it was mentioned that in the creation of very fast, in a few weeks, in a 88 01:08:50,520 --> 01:08:56,520 few months, of the vaccine against Covid, there was the fact that we could measure very 89 01:08:56,520 --> 01:09:01,760 quickly the results of a vaccine. A blood test is done and we know if the antibodies 90 01:09:01,760 --> 01:09:08,039 have developed or not. There is no such thing in Parkinson's disease and we can't just do a 91 01:09:08,039 --> 01:09:14,760 blood test and say you are sicker or less sick than before. And this is where my 92 01:09:14,760 --> 01:09:23,039 experience, both digital and scientific as a physicist, could help. 93 01:09:23,039 --> 01:09:31,359 And that's the challenge we tried to meet. In what way? In recent years, we have developed 94 01:09:31,359 --> 01:09:36,880 digital markers for Parkinson's disease. 95 01:09:36,880 --> 01:09:39,680 So, it has become our job. 96 01:09:39,680 --> 01:09:45,800 These digital markers, I started with the Typing pattern which is known in the 97 01:09:45,800 --> 01:09:51,399 cryptographic industry as being very characteristic of each person. 98 01:09:51,399 --> 01:09:56,880 And the studies, then, showed that the way of typing, the milliseconds of hesitation 99 01:09:56,880 --> 01:10:02,159 between two keys are characteristic of Parkinson's disease and its progress. So, 100 01:10:02,159 --> 01:10:09,479 here's a marker. Then, the analysis of the voice that we talked about earlier within the 101 01:10:09,479 --> 01:10:16,399 framework of the Iceberg protocol makes it possible to determine if a person has 102 01:10:16,399 --> 01:10:23,560 Parkinson's disease or not by measuring the stability in frequency and amplitude. 103 01:10:23,560 --> 01:10:30,199 And we want to go further, to measure the progress of Parkinson's disease in a given 104 01:10:30,199 --> 01:10:36,840 person through the analysis of phonation, but also through the analysis of speech 105 01:10:36,840 --> 01:10:40,039 recognition. So, it's coming together. 106 01:10:40,039 --> 01:10:43,880 The analysis of the tremor is very simple. 107 01:10:43,880 --> 01:10:52,039 Cell phones have an accelerometer and we rely on that to analyze tremor in patients who 108 01:10:52,039 --> 01:10:53,279 have tremor. 109 01:10:53,319 --> 01:10:59,199 And that is an objective measure, very easy to achieve. And finally, there is the 110 01:10:59,199 --> 01:11:06,399 measurement of the pathological component of beta waves that Nathalie George mentioned 111 01:11:06,399 --> 01:11:13,319 earlier in the context of neurofeedback. But it's also a marker for Parkinson's disease 112 01:11:13,319 --> 01:11:22,680 and the on-off state, etc. So the core of our activity is to gather all these 113 01:11:22,680 --> 01:11:30,680 neuro marker data and to process the collected data. 114 01:11:30,680 --> 01:11:35,039 How does it work? 115 01:11:35,039 --> 01:11:41,760 We have an app called DigiPark, which is available today on Google Play and in January 116 01:11:41,760 --> 01:11:48,359 it will be available on the Apple Store as well, which allows you to do several things 117 01:11:48,359 --> 01:11:54,800 for the science part. It allows to measure, to record a phonation we make "AAAAH" and 118 01:11:54,800 --> 01:12:02,279 that allows to analyze the amplitude and the intensity. We have a speech recognition part. 119 01:12:02,279 --> 01:12:05,920 We have a part for the tremor measurement. 120 01:12:05,920 --> 01:12:11,680 We are in the process of integrating a calligraphy part in order to measure the 121 01:12:11,680 --> 01:12:17,840 precise gestures of the patient and the application of My Brain Technology makes it 122 01:12:17,840 --> 01:12:24,119 possible to record the electroencephalogram and to make all the analysis which goes 123 01:12:24,119 --> 01:12:30,119 behind. The Typing Patern part, the way of typing, requires of course a computer 124 01:12:30,119 --> 01:12:37,239 keyboard. So, this application has several purposes, there is the scientific purpose 125 01:12:37,239 --> 01:12:43,840 that I just told you about, it's to retrieve data, but my first purpose was to help 126 01:12:43,840 --> 01:12:52,880 patients. And for that, we give this tool so that the patient can monitor his own 127 01:12:52,880 --> 01:12:58,560 symptoms. Patients must take the power, take back the power. 128 01:12:58,560 --> 01:13:04,079 It is a tool that goes in that direction. There is a simple pillbox tool. It's still 129 01:13:04,079 --> 01:13:12,199 nice to be able to track compliance and improve medication adherence. 130 01:13:12,199 --> 01:13:20,119 There is another phenomenon. Personally, I have among my symptoms of Parkinson's, there 131 01:13:20,119 --> 01:13:22,359 are diction problems. 132 01:13:22,359 --> 01:13:29,640 I go to see a very specialized, extremely competent speech therapist once a week. 133 01:13:29,640 --> 01:13:37,239 But between two sessions at the speech therapist, I have developed tools that allow 134 01:13:37,239 --> 01:13:44,479 me to follow and train on my own, but advised, of course, by the speech therapist. 135 01:13:44,479 --> 01:13:49,640 These tools are integrated in the DigiPark application. So, at the end of the day, it's 136 01:13:49,640 --> 01:13:54,199 an application that is provided free to all patients. 137 01:13:54,199 --> 01:14:02,199 Some of the patients agree to share their data with us and this data is kept completely 138 01:14:02,199 --> 01:14:08,199 anonymous, in compliance with the rules of the European Union. 139 01:14:08,199 --> 01:14:14,840 And these data allow us to develop tools, models that are then used in research and 140 01:14:14,840 --> 01:14:21,880 development to develop new therapies and, above all, to accelerate the release of new 141 01:14:21,880 --> 01:14:28,960 therapies. This is what the Typing Pattern looks like. 142 01:14:28,960 --> 01:14:36,119 It is a browser game where there are a series of words that are displayed on the screen. 143 01:14:36,159 --> 01:14:42,760 The person types the word and the computer records the milliseconds of hesitation 144 01:14:42,760 --> 01:14:51,680 between two keys or the pressing of a given key. This is the phonation and 145 01:14:51,680 --> 01:14:53,560 medication part. 146 01:14:53,560 --> 01:14:59,359 The same thing is recorded in a totally anonymous way, that is to say we don't know 147 01:14:59,359 --> 01:15:05,359 who is behind it, but we know that it is patient number 87 who made this recording. To 148 01:15:05,359 --> 01:15:14,479 illustrate very precisely, earlier, you saw the beta waves, these are not beta waves, they 149 01:15:14,479 --> 01:15:22,840 are simply the tremors of a patient's hand and so the tremors are visible on the left 150 01:15:22,840 --> 01:15:26,800 side. It is the hand that shakes. The analysis in terms of frequencies is on the 151 01:15:26,800 --> 01:15:31,880 right. And when you see a peak like that, centered around 4 or 5 Hz, that means 4 or 5 152 01:15:31,880 --> 01:15:37,520 times per second. This is really typical of a Parkinson's patient. These are the kinds of 153 01:15:37,520 --> 01:15:40,039 things we measure and record. 154 01:15:40,039 --> 01:15:42,079 In the same way earlier. 155 01:15:42,079 --> 01:15:48,720 You've heard about patient segmentation. The patients, you saw it on the genetic marker 156 01:15:48,720 --> 01:15:54,159 curve, but in the same way, no two Parkinson's patients are alike. 157 01:15:54,159 --> 01:15:58,800 Some people have trouble walking. Some people find it hard to talk. Some people have a lot 158 01:15:58,800 --> 01:16:04,680 of tremors and other symptoms. And thanks to our multimodal analysis, we are able to 159 01:16:04,680 --> 01:16:12,720 segment and approach personalized medicine. In the context of Parkinson's disease, the 160 01:16:12,720 --> 01:16:17,760 electroencephalogram part is very technical. 161 01:16:18,039 --> 01:16:27,239 So just now, you saw, it's kind of the same curves as Nathalie on the pathological Beta 162 01:16:27,239 --> 01:16:33,039 component. But there are also all the dynamics that can be analyzed in a much 163 01:16:33,039 --> 01:16:38,960 deeper way mathematically, with topological tools as on the right side. It is the 164 01:16:38,960 --> 01:16:45,840 platform that My Brain technology provides us that allows us to avoid reinventing the 165 01:16:45,840 --> 01:16:52,520 wheel. You always have to rely on the world's leading partner and I am pleased to have this 166 01:16:52,520 --> 01:16:57,880 tool there and to share it. So that's the name of the platform. I'm going behind. So, 167 01:16:57,880 --> 01:17:02,960 what have we achieved so far? I told you about the team, I told you about the 168 01:17:02,960 --> 01:17:08,680 approach. Now, what have we achieved in concrete terms? We have collected several 169 01:17:08,680 --> 01:17:16,000 thousands of experimental points, so it is very important because in biology, in 170 01:17:16,000 --> 01:17:23,640 medicine, when we have 10, 20, 50 patients and for each patient, we have a measurement 171 01:17:23,640 --> 01:17:25,319 point every month. 172 01:17:25,319 --> 01:17:30,319 We are very happy. Thanks to the digitalization of the tool, we have the 173 01:17:30,319 --> 01:17:36,439 possibility to have thousands of experimental points quickly. Here is the analysis of 1000 174 01:17:36,439 --> 01:17:40,880 experimental points. I will not go into detail because it is a publication that is in 175 01:17:40,880 --> 01:17:45,680 preparation, but we are already extremely enthusiastic with the preliminary results 176 01:17:45,680 --> 01:17:49,439 obtained. What are our strengths? 177 01:17:49,439 --> 01:17:55,239 Our strength is that we rely on artificial intelligence, of course, but also on ab 178 01:17:55,239 --> 01:18:00,159 initio modeling. We start from scratch without making any assumptions. It has been 179 01:18:00,159 --> 01:18:04,800 my specialty, while I was a physics researcher, to always start from a starting 180 01:18:04,800 --> 01:18:09,840 point with mathematical models that are confronted with the experiment in a complete 181 01:18:09,840 --> 01:18:14,520 way. This is called an ab initio model. We combine this with artificial intelligence. It 182 01:18:14,520 --> 01:18:20,079 allows us to go very fast. We are totally focused on patients. We are at the service of 183 01:18:20,079 --> 01:18:28,279 the patient and we seek to make personalized medicine. We have a complete set of neuro 184 01:18:28,279 --> 01:18:35,079 markers and all of this is stored in a database. 185 01:18:35,079 --> 01:18:43,119 We have outstanding partnerships and are supported by leading neurologists and 186 01:18:43,119 --> 01:18:52,079 researchers. And all this to improve patient management of the disease and to 187 01:18:52,079 --> 01:18:54,079 accelerate R&D. 188 01:18:54,079 --> 01:19:00,720 We benefit from an extremely favorable environment in France. Plus support from the 189 01:19:00,720 --> 01:19:02,199 Brain Institute. 190 01:19:02,199 --> 01:19:08,159 And we have a team with over 15 years of experience in digital health. We have here in 191 01:19:08,159 --> 01:19:14,880 the front row, for example, Dr Caroline Atlani, who has just joined us as chief medical 192 01:19:14,880 --> 01:19:19,720 officer. We have, I think, in visio Alfredo. 193 01:19:19,720 --> 01:19:26,760 Alfredo Alarcon who is a polytechnician with a decade of experience in 194 01:19:26,760 --> 01:19:30,239 data science in the biomedical field. 195 01:19:30,239 --> 01:19:36,039 So, we have an extraordinary team and we are totally oriented towards quick results. So, 196 01:19:36,039 --> 01:19:44,439 the years to come look quite good and I am very enthusiastic about the fact that we will 197 01:19:44,439 --> 01:19:52,640 be working with the pharmaceutical industry in the years to come to reduce the time 198 01:19:52,640 --> 01:20:00,840 needed to bring new therapies to market and to have our own medical devices to serve 199 01:20:00,840 --> 01:20:06,600 patients. It will serve the industry. 200 01:20:06,600 --> 01:20:11,720 It will serve neurologists in their relationships with their patients and it will 201 01:20:11,720 --> 01:20:18,840 serve the patients well, of course. And so, as a result, my initial objective, which was 202 01:20:18,840 --> 01:20:27,000 to achieve a virtuous circle on this will be achieved and I will be able to explain it to 203 01:20:27,000 --> 01:20:28,720 you a little more. 204 01:20:28,720 --> 01:20:33,760 So you see, at the bottom, this is the DiamPark Cie with the founders I told you 205 01:20:33,760 --> 01:20:42,039 about. We started by providing free services to patients and patients using our free 206 01:20:42,039 --> 01:20:49,039 services. Some of the patients provide their data and this data allows us to make models 207 01:20:49,039 --> 01:20:54,880 like the graph I showed you earlier. And these models make it possible to make 208 01:20:54,880 --> 01:21:01,319 breakthroughs and to provide hypotheses that are then validated by neurologists and 209 01:21:01,319 --> 01:21:06,920 researchers and that make it possible to produce tools that are used by the 210 01:21:06,920 --> 01:21:13,479 pharmaceutical industry during clinical trials to produce new therapies. Once we have 211 01:21:13,479 --> 01:21:18,159 that, patients are satisfied. That's the point. That was the goal, but also the 212 01:21:18,159 --> 01:21:23,640 investors are satisfied and it puts money back into the circuit and it allows to 213 01:21:23,640 --> 01:21:29,800 accelerate. And I hope it won't take 50 years to get the next therapies out. Thank you and 214 01:21:29,800 --> 01:21:35,159 if you have any questions I am at your disposal, thank you, 215 01:21:38,640 --> 01:21:42,520 We can take some questions. I don't know if there are any in the room. In any case, we 216 01:21:42,520 --> 01:21:49,760 have some on the chat channel. A first person who encourages you to create your educational 217 01:21:49,760 --> 01:21:56,920 tool. And one and one question do you share the work in artificial intelligence conducted 218 01:21:56,920 --> 01:21:58,720 by Google Mayo Clinic? 219 01:21:59,800 --> 01:22:02,399 So, Google Mayo Clinic? 220 01:22:02,399 --> 01:22:08,279 I unfortunately don't know. But if people could send me the link, I will look with 221 01:22:08,279 --> 01:22:15,720 great interest. Of course, we do an exhaustive bibliography and I had a graduate 222 01:22:15,720 --> 01:22:23,800 student on my team for several months who did an exhaustive bibliographic search. 223 01:22:23,800 --> 01:22:29,199 In addition to the work that all the rest of the team has done. But this particular group, 224 01:22:29,199 --> 01:22:30,439 I don't know. 225 01:22:30,439 --> 01:22:37,520 And it seems to me that it was Yohan who put us in touch. 226 01:22:37,520 --> 01:22:44,199 I've been particularly involved with researchers at Facebook because Facebook 227 01:22:44,199 --> 01:22:51,159 bought a company in the haptics field. And so unfortunately they totally stopped the 228 01:22:51,159 --> 01:22:58,000 medical research and they are now completely oriented to what makes the most money. 229 01:22:58,000 --> 01:23:05,399 But I tried to get what we could from the medical research of that team, for example. 230 01:23:05,760 --> 01:23:09,760 Very well, thank you very much. And one last question, but it seems to me that you, you 231 01:23:09,760 --> 01:23:14,319 have specified when will the application be available on Apple Store in January? January, 232 01:23:14,319 --> 01:23:16,039 in January? Perfect. 233 01:23:16,039 --> 01:23:21,479 Thank you very much. We have another question, is the application paid and are 234 01:23:21,479 --> 01:23:24,159 there specific criteria to use it? 235 01:23:25,000 --> 01:23:31,319 The application is totally free and that's something I'm very keen on and it can be used 236 01:23:31,319 --> 01:23:36,960 by everyone, without any conditions. When you use the application, you are asked to 237 01:23:36,960 --> 01:23:42,039 register because, on the one hand, it is the regulation and on the other hand, this 238 01:23:42,039 --> 01:23:47,039 registration, when you return to the application, allows you to find your data. 239 01:23:47,079 --> 01:23:52,119 But on the other hand, we don't ask you for your name, we don't ask you for your personal 240 01:23:52,119 --> 01:23:57,760 data, etc. And if you ever lose your password or your User, I can't find them for you 241 01:23:57,760 --> 01:24:03,840 because everything is totally anonymized so that no one can ever make the link between 242 01:24:03,840 --> 01:24:10,560 you, between the user and the databases. Our only goal is to get data that is then used to 243 01:24:10,560 --> 01:24:11,960 develop models. 244 01:24:12,000 --> 01:24:18,119 The data is never passed on to the pharmaceutical industry. I would also like to 245 01:24:18,119 --> 01:24:25,159 point out that during clinical trials, manufacturers come with their patients. 246 01:24:25,159 --> 01:24:30,760 They have access to their patients' data, but they do not have access to your data, even 247 01:24:30,760 --> 01:24:31,680 anonymously. 248 01:24:33,039 --> 01:24:37,319 Very well, thank you very much. there is one last question. Is this application is 249 01:24:37,319 --> 01:24:41,079 available on phones as well as on a web browser. 250 01:24:41,640 --> 01:24:47,079 So, you've figured out that there is one activity that requires an accelerometer. And 251 01:24:47,079 --> 01:24:53,720 on the browser, there are no accelerometers. Otherwise, the application is currently 252 01:24:53,720 --> 01:25:00,560 accessible on the cell phone only the typing pattern part is on browser. 253 01:25:00,560 --> 01:25:07,640 Plus computer keyboard. And we plan to have a slightly degraded version without the 254 01:25:07,640 --> 01:25:14,800 accelerometer that will be usable on a browser alone, on a desktop as well as on a 255 01:25:14,800 --> 01:25:17,159 computer with a keyboard. 256 01:25:17,159 --> 01:25:17,920 perfect thank you very much. 257 01:25:18,960 --> 01:25:19,319 Thank you.